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The Australian Customer’s V947 Autosampler Vial Order is Completed
The Australian Customer’s V947 Autosampler Vial Order is Completed
American Customer Ordered 100,000 Boxes of 9-425 2ml HPLC Vials
American Customer Ordered 100,000 Boxes of 9-425 2ml HPLC Vials
5000-boxes-of-blue-screw-cap-10-425-hplc-vial-sent-to-singapore
5000-boxes-of-blue-screw-cap-10-425-hplc-vial-sent-to-singapore
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Failure mode 1: septum coring and needle damage
Failure mode 1: septum coring and needle damage
April 5, 2018
Failure mode 1: septum coring and needle damage
I have watched a vial ruin a perfectly good sequence more times than I care to admit. The first time it happened, I was a junior analyst running a 96-well autosampler overnight and came back to a chromatogram that looked like a seismograph. The column was fine. The mobile phase was fresh. The problem was a batch of 2 mL vials with septum liners that had been sitting on the shelf for two years, and the silicone had hardened enough that the needle punched a core straight into the sample. That...
What an HPLC vial actually does
What an HPLC vial actually does
April 5, 2018
What an HPLC vial actually does
I have watched a lab save $40,000 a year on vials and then spend $90,000 on repeat injections because the septa were off-gassing into the headspace. I have also seen a QC group buy premium vials with the wrong neck geometry and jam a $200,000 autosampler. Vial selection is not a commodity decision. It sits at the intersection of chemistry, mechanical tolerance, and the specific instrument on your bench. This guide is what I tell procurement managers and lab supervisors when they ask me how ...
Why Vials Fail: The Three Failure Families
Why Vials Fail: The Three Failure Families
April 5, 2018
Why Vials Fail: The Three Failure Families
I have watched a lab lose three weeks of stability data because a single lot of crimp seals was 0.3 mm too thin, and I have seen an autosampler jam at 2 a.m. because someone bought the cheapest caps on the market. Most HPLC vial problems are not mysteries. They are predictable mechanical and chemical failures, and nearly every one of them is preventable with a few concrete specifications and a bit of discipline at the bench. This is the field guide I wish someone had handed me when I started...